Expression of genes of the IGF system in mononuclear cells from patients with acute lymphoblastic leukaemia (ALL) at diagnosis and at complete clinical remission (day 33 of treatment according BFM study protocol)
| ALL patients positive (%) | |||
|---|---|---|---|
| Genes | Diagnosis (N = 41) | Remission (N = 41) | p Value |
| Differences between groups were tested with the McNemar test. | |||
| *p≤0.05. | |||
| BFM, Berlin-Frankfurt-Münster; IGF, insulin-like growth factor; IGFBP, IGF binding protein; IGFBP-rP, IGFBP related protein; IGF-IIR, IGF-II receptor. | |||
| IGF-I | 24% | 39% | 0.210 |
| IGF-II | 63% | 78% | 0.180 |
| IGF-IR | 69% | 66% | 1.000 |
| IGF-IIR | 46% | 49% | 1.000 |
| IGFBP-1 | 0% | 0% | |
| IGFBP-2 | 59% | 56% | 1.000 |
| IGFBP-3 | 22% | 41% | 0.115 |
| IGFBP-4 | 34% | 27% | 0.664 |
| IGFBP-5 | 19% | 46% | 0.021* |
| IGFBP-rP1 | 18% | 10% | 0.453 |
| IGFBP-rP2 | 49% | 13% | 0.003* |