Comparison of loss of heterozygosity (LOH) frequencies between different regions of 3p in tumours with and without VHL inactivation
| % LOH frequencies | |||||
|---|---|---|---|---|---|
| 3p25 | 3p21–22 | 3p14 | 3p12 | 3p12–22 | Significance of difference between 3p12–22 and 3p25 |
| VHL inactivation is via methylation or mutation. | |||||
| The significance of the difference between 3p12–22 and 3p25 was measured using Fisher's exact test. | |||||
| VHL inactivation (VHL − ) | |||||
| 78 (30/39) | 85 (35/41) | 50 (8/16) | 62 (23/37) | 90 (37/41) | p = 0.14 |
| 3p LOH with no VHL inactivation (VHL + /LOH) | |||||
| 68 (17/25) | 89 (25/28) | 55 (6/11) | 52 (13/25) | 100 (28/28) | p = 0.0012 |
| Significance of difference for each region | |||||
| p = 0.560 | p = 0.43 | p = 1.0 | p = 0.45 | p = 0.14 | |