Summary of the effects of CD40 ligation on the panel of ovarian carcinoma cell lines
| Growth inhibition | Apoptosis induction | IL-6 production | IL-8 production | NF-κB activation | JNK activation | |
|---|---|---|---|---|---|---|
| The induction of apoptosis was determined by recombinant soluble CD40 ligand treatment in the presence of cycloheximide (CHX). Note that the OAW-28 cell line was extremely sensitive to CHX alone and that this precluded determination of the effect of CD40 ligation. IL, interleukin; JNK, c-jun N-terminal kinase. | ||||||
| SKOV-3 | − | − | + | + | − | + |
| A2780 | + | − | − | − | − | + |
| OAW-28 | + | − | − | + | + | + |
| MG75 | + | + | + | + | + | + |
| MG79 | + | + | + | + | + | + |