Table 1

Expression of Wnt ligands and Frizzled (Fz) 1/2 receptors in naevi and malignant melanoma

Tissue typeNWnt2Wnt5aWnt5bWnt7bWnt10bFz
Intensity of staining: −, negative; +, weakly positive; ++, strongly positive; +/−, variable expression pattern (some of the specimens tested were positive, either strongly or weakly, whereas others were negative).
Benign naevi15+++++/−+++++
Small, uniform melanoma cells14+++++/−+++++
Large, pleomorphic melanoma cells10++/−+/−+++