Expression of Wnt ligands and Frizzled (Fz) 1/2 receptors in naevi and malignant melanoma
| Tissue type | N | Wnt2 | Wnt5a | Wnt5b | Wnt7b | Wnt10b | Fz |
|---|---|---|---|---|---|---|---|
| Intensity of staining: −, negative; +, weakly positive; ++, strongly positive; +/−, variable expression pattern (some of the specimens tested were positive, either strongly or weakly, whereas others were negative). | |||||||
| Benign naevi | 15 | ++ | ++ | +/− | ++ | ++ | + |
| Small, uniform melanoma cells | 14 | ++ | ++ | +/− | ++ | ++ | + |
| Large, pleomorphic melanoma cells | 10 | − | + | +/− | +/− | ++ | + |