Regular ArticleConstitutive Activation of Wnt/β-Catenin Signaling Pathway in Migration-Active Melanoma Cells: Role of LEF-1 in Melanoma with Increased Metastatic Potential
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Angel or Devil ? - CDK8 as the new drug target
2021, European Journal of Medicinal ChemistryCitation Excerpt :The combination of WNT and Frizzled family receptor activates phosphorylation of drainheled (Dsh) and causes inactivation of GSK3β/APC/AXIN/β-catenin complex. The β-catenin released by the inactivated complex binds to TCF/LEF after be transferred into the nucleus and stimulates the TCF/LEF-dependent gene transcription [121–123]. In addition, E2F1 participates in controlling the cell cycle and the function of tumor suppressor genes.
RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/β-Catenin Signaling
2021, American Journal of PathologyBinding patterns and structure–activity relationship of CDK8 inhibitors
2020, Bioorganic ChemistryCitation Excerpt :Melanoma is regulated by the histone variant mH2A, and downregulation of this histone variant correlates with disease severity. Up-regulation of CDK8 may augment treatment of melanoma [59,60], by compensating for the loss of function resulting from downregulation of mH2A. Leveraging this indirect function of CDK8 to treat specific cancers is a novel therapeutic avenue [61,62].
PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/β-catenin signaling pathway
2018, Biomedicine and PharmacotherapyCitation Excerpt :These transformed the morphology of epithelial cells into mesenchymal cells to obtain the ability of migration [22–25]. Furthermore, the Wnt/β-catenin signaling pathway could induce EMT by inhibiting glycogen synthase kinase 3β-mediated phosphorylation and inhibiting the degradation of β-catenin, thereby promoting the migration and invasion of malignant tumor [24,26]. Given the promotion of TAMs on migration and invasion of tumor, we are interested in testing whether TAMs promote the migration and invasion of colon tumor, how the promotion is produced, and which signals are involved in this process.
Genetic Variants in WNT2B and BTRC Predict Melanoma Survival
2017, Journal of Investigative DermatologyEffects of Wnt-10b on proliferation and differentiation of murine melanoma cells
2015, Biochemical and Biophysical Research Communications
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