Regular ArticleEvaluation of Langerhans' Cells in the Cervical Epithelium of Women with Cervical Intraepithelial Neoplasia☆
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The vaginal microbiome: A complex milieu affecting risk of human papillomavirus persistence and cervical cancer
2022, Current Problems in CancerCitation Excerpt :Two studies evaluating surgical specimens (conization or hysterectomy) showed that there are fewer Langerhans' cells in healthy cervical tissue among smokers compared to non-smokers.143,144 Interestingly, fewer Langerhans’ cells are also noted in cervical tissue affected by high-grade dysplasia, although smoking has not been noted to further decrease the number of Langerhans cells in dysplastic tissue.143,145,146 The immune response to nicotine in the cervix bears further scrutiny to determine how it relates to HPV acquisition and persistence.
The morphology and distribution of CD1a positive Langerhans cells in normal and squamous cell carcinoma of cervix
2017, Journal of the Anatomical Society of IndiaCitation Excerpt :In this study, the mean number of LCs is less in cervix with squamous cell carcinoma. This is in accordance with Hubert et al., who noted that the density of CD1a positive LCs were low in the epithelium of squamous intraepithelial lesion (SIL) and squamous cell carcinoma biopsy specimens as compared with normal epithelium of exocervix19 and also with Conners et al., who reported a significant reduction in LCs in cervical dysplasia.20 It has been observed that both suppression of dendritic cell differentiation and dendritic cell apoptosis contribute to the reduction of dendritic cell numbers in cancer, thus associated with tumour progression.18
The human papillomavirus E7 oncoprotein as a regulator of transcription
2017, Virus ResearchThe Interaction Between Human Papillomaviruses and the Stromal Microenvironment
2016, Progress in Molecular Biology and Translational ScienceCitation Excerpt :LCs appear to be particular targets of HPV-induced immunosuppressive effects. A reduction of LCs has frequently been reported in HPV-containing CIN.208,294–302 HPV may suppress LC numbers by inhibiting migration into the tissue, by preventing differentiation into mature LCs, or by promoting premature migration out of the epithelium.
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Presented at the 27th meeting of the Western Association of Gynecologic Oncologists, Napa, CA, May 20–23, 1998.