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NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

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Abstract

We examined neuronal cytoplasmic inclusions (NCIs) and oligodendrocytic glial cytoplasmic inclusions (GCIs) in the pontine nuclei in multiple system atrophy (MSA) using antibodies against the non-amyloid β component of Alzheimer’s disease amyloid precursor protein (NACP/α-synuclein). Our immunohistochemical study revealed that anti-NACP antibodies labeled both NCIs and GCIs. Immunoelectron microscopy showed that positive reaction products were localized on the 15- to 30-nm-thick filamentous components of NCIs and GCIs. The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA, and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration.

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Authors and Affiliations

  1. Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan e-mail: arima@prit.go.jp, Tel.: +81-3-3304-5701, Fax: +81-3-3329-8035, , , , , , JP

    K. Arima & Minako Nakamura

  2. Department of Neurochemistry, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan, , , , , , JP

    Kenji Uéda & Haruko Tonozuka-Uehara

  3. Department of Laboratory Medicine, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP), Kodaira, Tokyo 187-8551, Japan, , , , , , JP

    Shigeo Hirai & Mitsuru Kawai

  4. Department of Neurology, National Center Hospital for Mental, Nervous, and Muscular Disorders, NCNP, Kodaira, Tokyo 187-8551, Japan, , , , , , JP

    Nobuhiko Sunohara & Kenji Arakawa

Authors
  1. K. Arima
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  2. Kenji Uéda
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  3. Nobuhiko Sunohara
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  4. Kenji Arakawa
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  5. Shigeo Hirai
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  6. Minako Nakamura
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  7. Haruko Tonozuka-Uehara
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  8. Mitsuru Kawai
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Received: 19 March 1998 / Revised, accepted: 23 June 1998

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Arima, K., Uéda, K., Sunohara, N. et al. NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy. Acta Neuropathol 96, 439–444 (1998). https://doi.org/10.1007/s004010050917

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  • DOI: https://doi.org/10.1007/s004010050917

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