Proteoglycan changes during restoration of transparency in corneal scars☆
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Hypoxia modulates the development of a corneal stromal matrix model
2018, Experimental Eye ResearchCitation Excerpt :Interestingly after corneal injury, fibronectin protein is transiently expressed, thus supporting the premise that the response to injury bears similarities to development (Zieske et al., 1987). Likewise, as corneal organization and clarity return after injury, so do the proteoglycan levels, which resemble those that occur in unwounded adult corneas (Hassell et al., 1983). In addition, injury that alters proteoglycan profiles and properties are associated with changes in the organization of collagen fibrils (Brown et al., 1999; Connon and Meek, 2003; Funderburgh et al., 1988).
Wound healing in the eye: Therapeutic prospects
2018, Advanced Drug Delivery ReviewsEpithelial basement membrane injury and regeneration modulates corneal fibrosis after pseudomonas corneal ulcers in rabbits
2017, Experimental Eye ResearchSmall leucine-rich repeat proteoglycans in corneal inflammation and wound healing
2016, Experimental Eye ResearchThe corneal fibrosis response to epithelial-Stromal injury
2016, Experimental Eye ResearchCitation Excerpt :Lumicans are thought to regulate collagenous matrix assembly in connective tissues via their bi-functional character. Thus, the protein moiety of lumican binds collagen fibrils at strategic loci and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacing (Funderburgh et al., 1995; Hassell et al., 1983; Kao and Liu, 2002). Chakravarti et al. (1998) have demonstrated that corneal opacity develops in Lum−/− mice and electron microscopic examination revealed abnormally thick collagen fibers, especially in the posterior stroma.
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This work was supported in part by Grant EY 01199 from the National Eye Institute and by funds obtained from the Massachusetts Lions Eye Research Funds Incorporated.
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Current address: Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Md. 20205.