Full paperRequirements for zygotic gene activity during gastrulation in Drosophila melanogaster☆
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Maintaining symmetry during body axis elongation
2023, Current BiologyExtremely rapid and reversible optogenetic perturbation of nuclear proteins in living embryos
2021, Developmental CellCitation Excerpt :This could reflect the ability of embryos to partially compensate for early loss of Twist. At this stage, the expression of many Twist targets are also supported by the TF Snail, whereas other transcripts are maternally deposited (Zusman and Wieschaus, 1985; Costa et al., 1994; Urbansky et al., 2016). Only twist and snail double mutants display a complete loss of ventral furrow (Leptin and Grunewald, 1990), whereas overexpression of snail can partly rescue gastrulation in twist mutant embryos (Seher et al., 2007; Wong et al., 2014).
Gastrulation in Drosophila melanogaster: Genetic control, cellular basis and biomechanics
2020, Mechanisms of DevelopmentCitation Excerpt :Consistent with the mutant phenotypes of twi and sna, many of the now known zygotic genes that control mesoderm morphogenesis in gastrulation are direct targets of Twi and Sna. One of the many transcriptional Twi target genes is folded gastrulation (fog), which encodes a secreted signaling protein (Dawes-Hoang et al., 2005; Peters and Rogers, 2013; Zusman and Wieschaus, 1985). In fog mutant embryos, cell shape changes are uncoordinated and result in a highly irregular VF (Costa et al., 1994; Dawes-Hoang et al., 2005).
The cellular and molecular mechanisms that establish the mechanics of Drosophila gastrulation
2020, Current Topics in Developmental BiologyCitation Excerpt :Twist and Snail regulate genes that modulate cell signaling to control cell shape change (Fig. 4A). In mesoderm and endoderm invagination, cell shape changes are associated with the expression of folded gastrulation (fog), a ligand for G-protein coupled receptors (GPCR) Mist and Smog, which lie upstream of RhoGEF2 activation (Costa et al., 1994; Dawes-Hoang et al., 2005; Fuse, Yu, & Hirose, 2013; Jha, van Zanten, Philippe, Mayor, & Lecuit, 2018; Kerridge et al., 2016; Manning, Peters, Peifer, & Rogers, 2013; Sweeton et al., 1991; Urbansky, González Avalos, Wosch, & Lemke, 2016; Xie & Martin, 2015; Zusman & Wieschaus, 1985). In addition, Twist expression in the mesoderm is associated with the expression of T48, a transmembrane protein that acts in parallel with Fog signaling to activate apical actomyosin contractility (Kölsch et al., 2007; Urbansky et al., 2016) (Fig. 4A).
Cell shape change and invagination of the cephalic furrow involves reorganization of F-actin
2015, Developmental BiologyCitation Excerpt :The identity of the initiator cells is specified by the anteroposterior patterning genes bicoid (bcd), hunchback (hb), buttonhead (btd), paired (prd) and eve (Blankenship and Wieschaus, 2001; Driever and Nusslein-Volhard, 1988; Frohnhofer and Nusslein-Volhard, 1986; Lehmann and Nusslein-Volhard, 1987; Namba et al., 1997; Payre et al., 1994; Schupbach and Wieschaus, 1986, 1989; Struhl et al., 1989; Vincent et al., 1997). Dorsoventral differences in CF depth depend on the dorsoventral patterning genes (Anderson et al., 1985; Costa et al., 1993; Irish and Gelbart, 1987; Roth et al., 1991; Rushlow and Levine, 1990; Zusman et al., 1988; Zusman and Wieschaus, 1985). Here, we characterize CF formation at the morphological and cellular levels.
BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization
2013, Developmental BiologyCitation Excerpt :We also assessed Gata-3 expression and protein content and found that Gata-3 expression (Fig. 9B) as well as protein level (Fig. 9C) were reduced in Twsg1−/− MGs. Studies in Drosophila melanogaster, Danio rerio, Xenopus, and Mus musculus have shown that TWSG1 is a highly conserved extracellular modulator of BMP signaling with important roles during embryonic development (Ross et al., 2001; Scott et al., 2001; Zusman and Wieschaus, 1985). Recent studies have demonstrated that TWSG1 continues to be an important BMP regulator in adult mammalian tissues, including bone homeostasis (Sotillo Rodriguez et al., 2009), regeneration following ischemic kidney injury (Larman et al., 2009), immune responses (Tsalavos et al., 2011), and, as this study shows, postnatal MG ductal maturation.
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This work was supported by NIH Grant HD15587 and a Basil O'Connor March of Dimes Research Grant 5-389 to Dr. Eric Wieschaus and by an NSF Graduate Fellowship to Susan Zusman.