Cytochrome P450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoma☆
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Cited by (179)
Fermented ginseng, GBCK25, ameliorates steatosis and inflammation in nonalcoholic steatohepatitis model
2019, Journal of Ginseng ResearchCitation Excerpt :It has been understood that CYP2E1-mediated ROS generation and consequent oxidative stress play pivotal roles in progression of both alcoholic and nonalcoholic steatohepatitis [9,10]. Therefore, several cancers and liver diseases are involved in genetic variation in CYP2E1 [11–13]. Although several human studies have investigated the genetic diversity of CYP2E1 in patients with NAFLD, the correlation between CYP2E1 variants and susceptibility to NASH remains undetermined [14,15].
Meta-analysis of CYP2E1 polymorphisms in liver carcinogenesis
2017, Digestive and Liver DiseaseCitation Excerpt :Results regarding the association between the polymorphisms of CYP2E1 and liver cancer from past years are inconsistent. Yu et al. proposed that individuals carrying the c1c1 genotype have a higher risk of liver cancer than the individuals carrying the more rare mutant c2c2 genotype [41]. However, Ladero et al. and Zhang et al. observed that individuals carrying the c2 mutant gene and long-term alcoholics have a higher risk of liver cancer than the individuals carrying the c1 allele [28,42].
Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease
2016, GastroenterologyCytochrome P450 in Cancer Susceptibility and Treatment
2015, Advances in Clinical ChemistryGene-environment interactions in heavy metal and pesticide carcinogenesis
2014, Mutation Research - Genetic Toxicology and Environmental MutagenesisGenetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: Association with hepatitis B related advanced liver disease and cancer
2013, GeneCitation Excerpt :Genetic alteration in DNA repair genes are associated with variations in the repair efficiency of DNA damage; which may eventually predispose an individual to cancer risk and a reduced life span (Ronen and Glickman, 2001). CYP2E1 expressed in liver activates various pro-carcinogens and therefore predisposes to liver diseases and cancer (Chen et al., 1997; Ingelman-Sundberg et al., 1993; Ladero et al., 1996; Yu et al., 1995). Functional polymorphism in this gene exhibit inter-individual variations in susceptibility towards various diseases and therapeutic response.
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Supported by grants DOH-H7707, DOH-H7903, DOH-H8003, DOH-H8103, and DOH-H8203 from the Department of Health, Executive Yuan; grant NSC83-0412-B-002-256 from the National Science Council of the Republic of China; and grant ESO 5116 from the National Institutes of Health.