Cell
ArticleCloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments
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Cited by (306)
Preferential combination between the light and heavy chain isotypes of fish immunoglobulins
2016, Developmental and Comparative ImmunologyCitation Excerpt :IgL gene configuration is classified as either “translocon” or “cluster” in genome and assembled by RAG-1 and RAG-2 through recognizing the recombination signal sequences (RSS) at the border of V and J segments (Criscitiello and Flajnik, 2007; Krangel, 2003; Mcblane et al., 1995). Mammalian IgL gene is organized as “translocon” arrangement, with multiple V and J segments arrayed upstream of C gene segments as (Vn-Jn-Cn) (Hieter et al., 1980; Hofker et al., 1989; Vasicek and Leder, 1990). Teleost and cartilaginous fish IgL genes exhibit a cluster-type organization as (V-J-C)n (Cannon et al., 2004; Criscitiello and Flajnik, 2007).
Expression and characterization of an enantioselective antigen-binding fragment directed against α-amino acids
2013, Protein Expression and PurificationCitation Excerpt :A similar strategy was applied to obtain mouse light chain constant region (CL) primers. Several published sequences were compared, namely a complete murine kappa chain constant sequence, oligonucleotides from murine CL primers, [59,60,64] amino acid and nucleotide sequences from various murine CL fragments, [65,66] and the sequence MOPC 21 # 8 from the Kabat database [53]. Among the query sequences, MOPC 21 # 8 resulted in the best match with the mouse CL sequence AB048524 (RefSeq ID); the highest score (Bits) was 588 and the E-value was 1e-165.
Genomic organization of the immunoglobulin light chain gene loci in Xenopus tropicalis: Evolutionary implications
2008, Developmental and Comparative ImmunologySpatial clustering of the IgE epitopes on the major timothy grass pollen allergen Phl p 1: Importance for allergenic activity
2006, Journal of Allergy and Clinical ImmunologyCitation Excerpt :The heavy-chain variable sequences of all 3 clones were most closely related to the same germline sequence (V genes: accession no. Z1233320; D genes: accession no. X9705121; J genes: accession no. X8635522). The light-chain variable regions of all 3 clones were also most closely related to one germline sequence (V genes: accession no. X5931223; J genes: accession no. J0024224). There were more exchanges in the CDRs of the heavy chains (18-24 nucleotides of 105; 17% to 23%) than in the FRs (5% to 8%, Table I).
Thermodynamic stability of a κI immunoglobulin light chain: Relevance to multiple myeloma
2005, Biophysical JournalCitation Excerpt :ESI MS was used to confirm the sequence analysis of MM-κI (Fig. 1). The observed mass of 23,514 ± 2 Da (Fig. 1 A) was not consistent with the calculated mass of 23,395 Da obtained using the MM-κI VL conventional sequence data and the published structure of the κ-CL domain (Hieter et al., 1980). The calculated mass assumed that two disulfide bonds were present, Cys23–Cys88 and Cys134–Cys194.