Cell
Volume 62, Issue 3, 10 August 1990, Pages 503-514
ArticleHigh levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines
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Cited by (652)
DNA methylation: a historical perspective
2022, Trends in GeneticsCitation Excerpt :In parallel with these plant studies, the Bestor and Schübeler labs used similar enrichment-based techniques to create the first comprehensive maps of human DNA methylation [202,203]. These maps strengthened previous work supporting the idea that promoter CGIs are predominantly unmethylated in normal human cells; however, the Schübeler lab found hypermethylation at CGIs in one colon cancer cell line, consistent with the earlier observations of the Bird lab [135]. Interestingly, this cell line also showed notable hypomethylation across large gene-poor domains and the inactive X chromosome [202].
Dynamic antagonism between key repressive pathways maintains the placental epigenome
2023, Nature Cell Biology
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