Cell
Volume 60, Issue 3, 9 February 1990, Pages 487-494
ArticleCyclin is a component of maturation-promoting factor from Xenopus
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2021, Journal of Biological ChemistryCitation Excerpt :Cyclin/CDK complexes activate cell cycle proteins essential for transition to the next cell cycle phase, while CDK inhibitors interfere with cyclin/CDK complex formation (34). The decision to enter mitosis primarily depends on CDK1 activity after the initiation of the G2/M transition, and CDK1 and cyclin B form a complex to become part of the M-phase promoting factor (35, 36). Importantly, CDK1 activity is negatively regulated by WEE1, which catalyzes inhibitory phosphorylation of tyrosine 15 on CDK1 (37).
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Present address: Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143.
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