Regional chromosome localization of human papillomavirus intergration sites near fragile sites, oncogenes, and cancer chromosome breakpoints☆
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Cited by (93)
MicroRNAs are important players in head and neck carcinoma: A review
2013, Critical Reviews in Oncology/HematologyCitation Excerpt :Integration of the HPVs seems to occur randomly throughout the whole host genome, mostly in non-coding sequences, having no pathogenic effect. However, some authors have speculated about its potential preference for sequences involving chromosomal fragile sites that harbor genes like the tumor suppressor FHIT at 3p14, the MYC protooncogene at 8q24, several loci within the hTERT promoter region at 5p15.14 [105–107], and many others. Interestingly, HPV-positive patients have totally different molecular characteristics than other HNSCC patients.
Do retroviruses preferentially integrate within highly plastic regions of the human genome?
2003, Medical HypothesesMulti-omics mapping of human papillomavirus integration sites illuminates novel cervical cancer target genes
2021, British Journal of Cancer
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This work was supported by a program project grant on Fragile Sites and Cancer Cytogenetics (P01 CA-41124) from the National Cancer Institute.
Copyright © 1988 Published by Elsevier Inc.