Rapid paperHuman thyrotropin receptor gene: Expression in thyroid tumors and correlation to markers of thyroid differentiation and dedifferentiation
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2016, Medical EpigeneticsInhibition of miR-146b expression increases radioiodine-sensitivity in poorly differential thyroid carcinoma via positively regulating NIS expression
2015, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Moreover, it has been reviewed the tremendous potential of miRNAs for use in the diagnosis and prognosis of thyroid tumors, including miR-196, miR-146b, miR-155 and so on [8–10]. Differentiated thyroid cells express a number of differentiation markers such as thyroglobulin (Tg), thyroperoxidase (TPO) and the Na+/I− symporter (NIS), that are responsible for iodine uptake, synthesis of thyroid hormones and the differentiated thyroid phenotype [11]. Studies have revealed that decreased TSH receptor (TSHR) expression correlate with FTC-133 ongoing dedifferentiation after 131I radiation, while TSHR transfection can also improve the expression of thyroid-specific molecules, including TSHR, NIS and TPO, and radioiodine uptake (RAIU) [12,13].
Thyroid Regulatory Factors
2015, Endocrinology: Adult and PediatricTargeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes
2014, BiomaterialsCitation Excerpt :TSHr expression is maintained in most thyroid pathologies, including benign and malignant tumors [18–23]. More importantly, the receptor is also present in the majority of less differentiated and more aggressive tumors [18–23], making it an optimal target for the delivery of chemotherapeutics. 1,2-dipalmitoyl-sn-glycero-3-phospocholine monohydrate (DPPC) and N-(carbonyl-methoxypolyethylene glycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE-mPEG2000) were purchased from Genzyme (Suffolh, UK).
The current role of targeted therapies to induce radioiodine uptake in thyroid cancer
2014, Cancer Treatment ReviewsCitation Excerpt :TPO in TC is suppressed at both the mRNA and protein level in some studies while according to others it is not altered [27,28]. Levels of Tg mRNA varying from normal to complete loss in TC are seen [29,30]. Decreases in Tg were not related to dys-regulation of pathways common in TC [31].
Coexistence of Graves' disease, papillary thyroid carcinoma and unilateral benign struma ovarii: Case report and review of the literature
2013, Metabolism: Clinical and Experimental