The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma
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Insulin-like growth factor 1 regulates excitatory synaptic transmission in pyramidal neurons from adult prefrontal cortex
2022, NeuropharmacologyCitation Excerpt :Taken together, our data showed that the inhibition effect of IGF1 on eEPSC amplitude was mediated through mGluR1-induced AMPAR endocytosis. The expression levels of IGF1 and IGF1R fluctuate throughout lifetime: the expression levels of IGF1 and IGF1R peak during developmental stage, but both IGF1 and IGF1R are widely presented in adult human and rodent brain (Aguado et al., 1994; Araujo et al., 1989; Ayer-le Lievre et al., 1991; Bach et al., 1991; Bondy and Lee, 1993; Han et al., 1988; Sandberg et al., 1988). IGF1 in the brain can be locally produced by all cell types (with a diffuse expression pattern in the cortex) (Bach et al., 1991), and circulating IGF1 can also enter the brain through choroid plexus and blood brain barrier (Carro et al., 2000, 2002; Nishijima et al., 2010; Trejo et al., 2001).
Pheromones Modulate Learning by Regulating the Balanced Signals of Two Insulin-like Peptides
2019, NeuronCitation Excerpt :Previous studies in mammals and invertebrates have implicated insulin and ILPs in modulating brain functions in response to environmental cues, including food signals, to regulate behavior, particularly those important for seeking food, such as olfaction (Deijen et al., 1998; Marks et al., 2009; Root et al., 2011; Wu et al., 2005). Because insulin and ILPs are widely expressed in the nervous system, they often play critical roles in processing diverse sensory inputs (Aguado et al., 1994; Chen et al., 2013; Cornils et al., 2011; Li et al., 2003; Pierce et al., 2001; Ritter et al., 2013; Sandberg et al., 1988; Stylianopoulou et al., 1988; Tomioka et al., 2006). Because pheromones can signal population density, which is an important piece of social information critical for food availability, insulin and ILPs are candidate effectors of the pheromone-mediated modulation of olfactory learning.
Insulin-like growth factor (IGF) axis in cancerogenesis
2017, Mutation Research - Reviews in Mutation ResearchCitation Excerpt :IGF axis was also investigated in bone and soft tissues cancers, hematologic malignancies, central nervous system neoplasms, urinary tract neoplasms, and thyroid cancer [16,390]. In glioblastomas IGF-1 expression was 1.1–4.0-fold greater than in normal brain tissue, and the positive correlation between IGF-1 immunoreactivity and the histopathological grade of the cancer was observed [391]. Genua et al. demonstrated that the IGF-1R is overexpressed in invasive urinary bladder cancer tissues and promotes motility and invasion of urothelial carcinoma cell [392].
RNA-binding protein insulin-like growth factor mRNA-binding protein 3 (IMP-3) promotes cell survival via insulin-like growth factor II signaling after ionizing radiation
2011, Journal of Biological ChemistryCitation Excerpt :The fetal growth factor IGF-II plays a pivotal role in embryonic development. Its expression is very high in the fetus and some tumors, whereas its abundance is greatly reduced or absent in adult tissues (19–27). Its oncofetal expression pattern is similar to that of IMP-3 (1).
Regulation and Mechanism of Growth Hormone and Insulin-like Growth Factor-I Biosynthesis and Secretion
2006, The Somatotrophic Axis in Brain Function