Original paperMolecular genetic analysis of the von Hippel-Lindau disease (VHl) tumour suppressor gene in gonadal tumours
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Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon over expression of miR142-3p microRNA
2013, Journal of Biological ChemistryCitation Excerpt :An isochromosome of the short arm of chromosome 12 is the most common and characteristic cytogenetic aberration in TGCTs. In addition, molecular genetic changes in human TGCTs showed 3p allele loss, suggesting the presence of a tumor suppressor gene within this region (13–15). Notably, the PTPN23 gene is located within this region (chromosome 3p21.3) in an area of the genome frequently lost in breast (16), lung (17), nasopharyngeal (18), cervical (19), and kidney (20) carcinomas.
Chromosomes, genes, and development of testicular germ cell tumors
2004, Cancer Genetics and CytogeneticsThe VHL tumour-suppressor gene paradigm
1998, Trends in GeneticsRole of VHL gene mutation in human cancer
2004, Journal of Clinical Oncology
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