Clinical studyThe use of recombinant thyrotropin in the follow-up of patients with differentiated thyroid cancer
Section snippets
Recombinant thyrotropin
The development of recombinant thyrotropin in the early 1990s provided a novel way to follow patients with thyroid cancer. Recombinant thyrotropin can be produced by transfecting the TSH-α and TSH-β subunit genes subunits into Chinese hamster ovary cells, a genetically modified cell lineage. Recombinant thyrotropin stimulates the accumulation of cyclic adenosine monophosphate, cellular growth, and the production of thyroglobulin from fetal thyroid cells (9). In normal subjects, recombinant
Acknowledgements
The authors express their gratitude to Dr. Matthew D. Ringel for his thoughtful suggestions.
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