Biochemical and Biophysical Research Communications
Insulin-like growth factor-binding protein-1 inhibits binding of IGF-I on fetal skin fibroblasts but stimulates their DNA synthesis
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2015, Molecular and Cellular EndocrinologyCitation Excerpt :IGFBP-1 functions by binding IGF-I and sequestering it from its receptor, IGF-1R, consequently preventing it from transducing mitogenic signals (Clemmons et al., 1995; Firth and Baxter, 2002; Valentinis and Baserga, 2001). Phosphorylation of IGFBP-1 increases the binding affinity of IGFBP-1 for IGF-I (Jones et al., 1991) and sequesters IGF-I, thereby decreasing IGF-I bioavailability (Firth and Baxter, 2002; Koistinen et al., 1990; Wong et al., 1999; Yu et al., 1998). Human FGR fetuses often have decreased fetal circulating levels of essential amino acids, such as leucine (Regnault et al., 2013; Sathishkumar et al., 2011; Teodoro et al., 2012; Wu, 2009).
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