Original contributionProliferative characteristics of intestinalized mucosa in the distal esophagus and gastroesophageal junction (short-segment Barrett's esophagus): A case control study☆
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Cited by (28)
Neoplastic Precursor Lesions in Barrett's Esophagus
2007, Gastroenterology Clinics of North AmericaCitation Excerpt :For example, in a study by Yu and colleagues [50] using high-fidelity image cytometry performed on 66 nondysplastic Barrett's esophagus specimens, mild aneuploidy was detected in 69% of cases. Also, nondysplastic Barrett's esophagus shows proliferative abnormalities and various degrees of loss of cell cycle regulation [51,52], both of which are cardinal features of a “neoplastic” process. These findings hold promise that biomarkers of malignant potential may eventually be defined in predysplastic mucosa.
Barrett's esophagus: An update
2003, Critical Reviews in Oncology/HematologyClassification of Barrett's epithlium by magnifying endoscopy
2002, Gastrointestinal EndoscopyCitation Excerpt :The Ki-labeling indices for specimens from mucosa with a pit pattern equivalent to intestinal type epithelium were higher than those for specimens from gastric type mucosa. Gulizia et al.24 reported that intestinalized epithelium in Barrett's esophagus or short segment Barrett's esophagus has increased proliferative activity in comparison with mucosa without intestinalized epithelium. These findings further support the use of magnifying endoscopy to detect intestinalized epithelium within Barrett's epithelium.
Prospective evaluation of multilayered epithelium in Barrett's esophagus
2001, American Journal of GastroenterologyCitation Excerpt :In 1961, Hayward suggested that the distal 2–3 cm of esophageal mucosa might “normally” be lined by gastric cardia-type mucinous epithelium (11), indicating that the finding of gastric mucinous epithelium in the distal esophagus does not necessarily represent a metaplastic phenomenon. However, although controversial, several recent immunohistochemical and pathological studies suggest that the presence of cardia-type mucinous epithelium in the distal esophagus is an abnormal finding, and probably represents a metaplastic process (6, 12–15). For instance, in an elegant clinicopathological biopsy study of 71 patients, all of whom had mucosal biopsies obtained from the gastroesophageal junction, Chandrasoma et al. showed that the presence of cardia-type, or oxynto-cardia-type, mucosa correlated strongly with the presence and amount of abnormal acid exposure (12).
Biomarkers in Barrett esophagus
2001, Mayo Clinic ProceedingsCitation Excerpt :Interestingly, with increasing dysplasia, the fraction of proliferating cells and the size of the proliferative compartment increase, and an upward shift of the proliferative compartment within the villi occurs. Eventually, in high-grade dysplasia, luminal epithelial cells show proliferative activity.9–17 After regression of dysplasia or reversal to squamous epithelium, the proliferative activity is decreased.
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Presented in part at the 1998 Annual Meeting of the USCAP, Boston, MA.