Cell
Volume 109, Issue 4, 17 May 2002, Pages 409-412
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Sex, AGility, and the Regulation of Alternative Splicing

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Abstract

Alternative splicing is an important means of regulating the expression of eukaryotic genes and enhancing protein diversity. A detailed examination of the Drosophila Sex-lethal gene has led to two significant discoveries—the role of the splicing factor SPF45 in defining the site of exon ligation, and that alternative splicing can be regulated at the second step.

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