International Journal of Radiation Oncology*Biology*Physics
Original contributionMammary recurrences in women younger than forty☆
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Cited by (126)
Rates of residual disease with close but negative margins in breast cancer surgery
2015, BreastCitation Excerpt :Achieving excellent local control has many influences beyond margin width and adjuvant therapy, including preoperative planning, operative execution, and meticulous intraoperative and postoperative pathologic assessment. In addition, it is known that patient factors such as young age [26–28], and several adverse disease markers [17–21,26,29–32] are associated with a higher risk of local recurrence. Punglia et al. cited a number of risk factors for local recurrence and ranked them in order of importance: positive margins, young age, lack of systemic therapy, close margins, LVI and axillary-node involvement for BCT; and increasing number of positive axillary nodes, lack of systemic therapy, positive margins, close margins, tumor size, young age and LVI for mastectomy [33].
Similar survival with breast conservation therapy or mastectomy in the management of young women with early-stage breast cancer
2012, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :Importantly, poorer outcomes in the youngest cohort were seen in multivariable analysis even after controlling for baseline tumor characteristics (including histology, grade, ER/PR status, T stage, and N stage). Although the lack of local recurrence data in the SEER database precluded analysis according to this important endpoint in our study, several previous series have demonstrated increased local recurrence rates among young women undergoing BCT (10–19). The apparent differences in local recurrence rates between the BCT and mastectomy series may be at least partly explained by the difficulty in differentiating between local recurrences and secondary breast cancers in the setting of BCT.
The Impact of Age on Outcome in Early-Stage Breast Cancer
2011, Seminars in Radiation OncologyBreast Cancer in Premenopausal Women
2009, Current Problems in SurgeryCitation Excerpt :However, their multivariate analysis showed that age was not an independent risk factor, although other morphologic risk factors, some of which are more common in younger women (see Table 6), were significant, such as major lymphocytic stromal reaction, extensive intraductal component, grade 3 tumors, and closer resection margin.80 In an analysis of a larger series of 1382 patients, Kurtz and colleagues found no difference in OS between younger and older age groups, either in those with no recurrence or those who had required salvage surgery for treatment of an operable recurrence.81 In contrast, other analyses have demonstrated young age to be an independent risk factor for LR after BCT.
Analysis of local regional recurrences in breast cancer after conservative surgery
2009, Annals of OncologyTen-Year Recurrence Rates in Young Women With Breast Cancer by Locoregional Treatment Approach
2009, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :Definitions of “young age” have been controversial, with some studies suggesting that cutoff points at age 30, 35, and 40 years all segregate a “young” population that does more poorly than similarly staged “older” patients. However, many series found that patients 35 years or younger consistently have higher locoregional recurrence (LRR) rates when treated with breast-conserving therapy (BCT) (1–9), and some have reported that this translates into decreased overall survival (OS) (7). Breast cancer in young patients has been hypothesized to be more biologically aggressive than that occurring in older cohorts based on histopathologic features, including higher grade, more lymphovascular space invasion (LVSI), more extensive intraductal component, and more estrogen receptor (ER) negativity (1, 6, 10, 11).
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Presented at the Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Boston, October 22, 1987.