Baillière's Clinical Gastroenterology
7 The inheritance of alcoholic liver disease
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Cited by (18)
Fatty Liver Disease
2023, MacSween's Pathology of the Liver, Eighth EditionFatty Liver Disease
2018, MacSween's Pathology of the LiverGenetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population
2012, GeneCitation Excerpt :Only 10–30% of alcoholics develop clinically significant liver disease and suffer from morbidities arising thereof. This lack of dose–response relationship along with inter-individual and racial differences in the propensity to ALD, together with evidence arising from twin concordance studies in alcoholic cirrhosis strongly points to the contribution of genetic factors in development of alcoholic liver dysfunction (Bassendine and Day, 1998; Stickel and Sterreicher, 2006). ALD, therefore, is a classic complex trait where a number of pathological and clinical phenotypes accumulate over a period of exposure driven by an intricate host–environment interaction.
Fatty liver disease. Alcoholic and non-alcoholic
2012, MacSween's Pathology of the LiverFatty Liver Disease: Alcoholic and Non-Alcoholic
2011, MacSween's Pathology of the Liver: Expert Consult: Online and PrintPolymorphisms in the interleukin-10 gene promoter and the risk of alcoholism and alcoholic liver disease in Caucasian Spaniard men
2010, AlcoholCitation Excerpt :Genetic studies have been conducted to explain why only a minority of alcoholic patients develop ALD. Most of them have been focused on genes encoding ethanol-metabolizing enzymes (Bassendine and Day, 1998; Lorenzo et al., 2006; Vidal et al., 2004; Whitfield, 1997). Because there is increasing evidence that cytokines play an important role in the pathogenesis of ALD (Crews et al., 2006), the effects of the polymorphisms in the genes that encode for pro- and anti-inflammatory cytokines have been studied with discordant results (Auguet et al., 2008; Grove et al., 2000; Ladero et al., 2002; Richardet et al., 2006).