The genetic regulation of apoptosis

doi:10.1016/S0959-437X(95)90060-8

Current Opinion in Genetics & Development

Volume 5, Issue 1, February 1995, Pages 97-104

https://doi.org/10.1016/S0959-437X(95)90060-8 Get rights and content

Abstract

Dramatic advances, most of them within the past two years, have provided a picture of the genetic regulation of apoptosis in mammalian cells. Although much detail remains to be filled in, the general structure—concordant with programmed death in invertebrates—includes signalling systems, genetic determination of susceptibility, critical proteins capable of reversing or re-affirming the death sentence, and a common effector pathway driven by specific proteases.

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The genetic regulation of apoptosis

Abstract

Cell

Science

J Biol Chem

Nature

Cell

Cell

Genes Dev

Int J Oncol

Genes Dev

Mol Cell Biol

Towards an understanding of the molecular mechanisms of physiological cell death

Bcl-2 and the regulation of programmed cell death

J Cell Biol

Cell death in health and disease: the biology and regulation of apoptosis

Semin Cancer Biol

Programmed cell death and the control of cell survival: lessons from the nervous system

Science

Programmed cell' death induced by ceramide

Science

Induction of apoptotic DNA degradation and cell death by activation of the sphingomyelin pathway

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

J Exp Med

Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis

Cancer Res

Fas and its ligand in a general mechanism of T-cell mediated cytotoxicity

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death

EMBO J

Molecular cloning and expression of the Fas ligand, a novel member of the tumour necrosis factor family

Cell

Purification and characterisation of the fas ligand that induces apoptosis

J Exp Med

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

Nature

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77

Nature

Induction of apoptosis in fibroblasts by c-Myc protein

Cell

The c-myc protein induces cell cycle progression and apoptosis through dimerization with max

EMBO J

p53-dependent apoptosis produced by Rb deficiency in the developing mouse lens

Nature

Requirement for a functional Rb-1 gene in murine development

Nature

p53-dependent G1 arrest involves prb-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein

Stabilisation of the p53 tumor suppressor is induced by adenovirus 5E1A and accompanies apoptosis

Genes Dev

Wild type p53 mediates apoptosis by E1A which is inhibited by E1B

Genes Dev

Induction of apoptosis by adenovirus type 5E1A in rat cells requires a proliferation block

Oncogene

Mediation of c-myc-induced apoptosis by p53

Science

Thymocyte apoptosis induced by p53-dependent and independent pathways

Nature

p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following γ-irradiation

Oncogene

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

Cell

c-myc-induced apoptosis in fibroblasts is inhibited by specific cytokines

EMBO J

Differential effects of the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

Nature

p53-dependent apoptosis in the absence of transcriptional activational of p53 target genes

Nature

Induction of p21 (WAF-1/CIP-1) during differentiation

Oncogene

Induction of WAF1/CIP1 by a p53-independent pathway

Cancer Res