The lineage commitment of haemopoietic progenitor cells

https://doi.org/10.1016/S0959-437X(97)80007-XGet rights and content

Abstract

Multipotent haemopoietic progenitor cells appear to be ‘primed’ for commitment by co-expression of a multiplicity of genes characteristic of different lineages. Lineage commitment proceeds as the consolidation of a distinct pattern of gene expression out of this milieu.

References (53)

  • SR McKercher et al.

    Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities

    EMBO J

    (1996)
  • AD Whetton et al.

    Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony forming cells

    J Cell Biol

    (1994)
  • HJ Lawrence et al.

    The role of HOX homeobox genes in normal and leukaemic hematopoiesis

    Stem Cells

    (1996)
  • AM Ford et al.

    Immunoglobulin heavy-chain and CD3 delta-chain gene enhancers are DNasel-hypersensitive in hemopoietic progenitor cells

    Proc Natl Acad Sci USA

    (1992)
  • R Festenstein et al.

    Locus control region function and heterochromatin induced position effect variegation

    Science

    (1996)
  • DG Tenen et al.

    Transcription factors normal myeloid development and leukaemia

    Blood

    (1997)
  • CS Lin et al.

    Differential effects of an erythropoietin receptor disruption on primitive and definitive erythropoiesis

    Genes Dev

    (1996)
  • SA Ness et al.

    Vintage reds and whites: combinatorial transcriptional factor utilization in hematopoietic differentiation

    Curr Opin Genet Dev

    (1994)
  • MA Cross et al.

    Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line

    Oncogene

    (1994)
  • SH Orkin

    Development of the hematopoietic system

    Curr Opin Genet Dev

    (1996)
  • M Hu et al.

    Multilineage gene expression precedes commitment in the hemopoietic system

    Genes Dev

    (1997)
  • L Silver et al.

    Initiation of murine embryonic erythropoiesis: a spatial analysis

    Blood

    (1997)
  • C Porcher et al.

    The T cell leukaemia oncoprotein SCL/Tal-1 is essential for development of all hematopoietic lineages

    Cell

    (1996)
  • L Robb et al.

    The SCL gene product is required for the generation of all haematopoietic lineages in the adult mouse

    EMBO J

    (1996)
  • P Melotti et al.

    Induction of hematopoietic commitment and erythromyeloid differentiation in embryonal stem cells constitutively expressing c-myb

    Blood

    (1996)
  • M Oelgeschlager et al.

    C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter

    Mol Cell Biol

    (1996)
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