Current Biology
Volume 11, Issue 15, 7 August 2001, Pages R592-R595
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Wnt signalling: Antagonistic Dickkopfs

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Abstract

Dickkopf proteins are secreted antagonists of the Wnt cell signalling molecules, which have a novel mode of action. Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt–Frizzled–LRP5/6 receptor complexes, thus blocking the canonical Wnt–β-catenin pathway.

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