Abstract
At least two types of somatic recombination are necessary for the generation of a complete immunoglobulin γ2b gene from germ-line DNA sequences. The first type of recombination consists of the assembly of three separate DNA segments, each encoding a different part of the variable region. The second type of recombination replaces the exons coding for the constant region of the μ chain with those coding for the same region of the -γ2b chain. The DNA sequencing studies suggest that the two types of recombination operate by different mechanisms.
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Sakano, H., Maki, R., Kurosawa, Y. et al. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes. Nature 286, 676–683 (1980). https://doi.org/10.1038/286676a0
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DOI: https://doi.org/10.1038/286676a0
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