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Loss of genes on the short arm of chromosome 11 in bladder cancer

Abstract

Recent studies have shown that normal cellular sequences on chromosome 13 are lost during the development of retinoblastomas1 and that sequences on chromosome 11 are similarly lost during the development of Wilms' kidney tumours2–5 and embryonal tumours6. Cells from these tumours have been found to contain either the paternal or maternal copies of loci on the affected chromosome, but not both. Thus, the somatic loss of heterozygosity for sequences on chromosome 13 or 11 is hypothesized to result in homozygosity for a recessive mutant allele on these chromosomes1, and in this way the chromosomal loss may contribute to the development of these tumours. We sought to investigate whether similar losses of heterozygosity for chromosome 11 sequences occurred in a common adult tumour. We chose to analyse bladder cancers, since such cancers are common in the adult population and are derived from urogenital tissue, as are Wilms' tumours. We examined constitutional and tumour genotypes at loci on the short arm of chromosome 11 (11p) in 12 patients with transitional cell carcinomas. In five tumours, we observed the somatic loss of genes on 11p resulting in homozygosity or hemizygosity of the non-deleted alleles in the tumour cells. Our results show that the frequency of loss of 11p sequences in bladder cancer approaches that seen in Wilms' tumour (42% compared with 55%)7, and suggest that recessive genetic changes involving sequences on 11p may contribute to the development of bladder neoplasms.

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References

  1. Cavenee, W. K. et al. Nature 305, 779–784 (1983).

    Article  ADS  CAS  Google Scholar 

  2. Koufos, A. et al. Nature 309, 170–172 (1984).

    Article  ADS  CAS  Google Scholar 

  3. Orkin, S. H., Goldman, D. S. & Sallan, S. E. Nature 309, 172–174 (1984).

    Article  ADS  CAS  Google Scholar 

  4. Reeve, A. E. et al. Nature 309, 174–176 (1984).

    Article  ADS  CAS  Google Scholar 

  5. Fearon, E. R., Vogelstein, B. & Feinberg, A. P. Nature 309, 176–178 (1984).

    Article  ADS  CAS  Google Scholar 

  6. Koufos, A. et al. Nature 316, 330–334 (1985).

    Article  ADS  CAS  Google Scholar 

  7. Solomon, E., 309, 111–112 (1984).

  8. Fisher, J. H. et al. Somat. Cell Molec. Genet. 10, 455–464 (1984).

    Article  CAS  Google Scholar 

  9. Capon, D. J., Charen, E. Y., Levinson, A. D., Seeburg, P. H. & Goeddel, D. V. Nature 302, 33–37 (1983).

    Article  ADS  CAS  Google Scholar 

  10. Harper, M. E., Ullrich, A. & Saunders, G. A. Proc. natn. Acad. Sci. U.S.A. 75, 4458–4460 (1981).

    Article  ADS  Google Scholar 

  11. Bell, G. I., Selby, M. J. & Rutter, W. J. Nature 295, 31–35 (1982).

    Article  ADS  CAS  Google Scholar 

  12. Goelz, S. E., Hamilton, S. R. & Vogelstein, B. Biochem. biophys. Res. Commun. 130, 118–126 (1985).

    Article  CAS  Google Scholar 

  13. Adcock, M. W. & O'Brien, W. P. J. biol. Chem. 259, 13471–13476 (1984).

    CAS  PubMed  Google Scholar 

  14. Wyman, A. R. & White, R. Proc. natn. Acad. Sci. U.S.A. 77, 6754–6758 (1980).

    Article  ADS  CAS  Google Scholar 

  15. Gibos, Z., Prout, G. R., Connally, J. G., Pontes, J. E. & Sandberg, A. A. Cancer Res. 44, 1257–1264 (1984).

    Google Scholar 

  16. Atkin, N. B. & Baker, M. C. Cancer Genet. Cytogenet. 15, 253–268 (1985).

    Article  CAS  Google Scholar 

  17. Kondo, K., Chilcote, R. R., Mauver, H. S. & Rowley, J. D. Cancer Res. 44, 5376–5381 (1984).

    CAS  PubMed  Google Scholar 

  18. Comings, D. E. Proc. natn. Acad. Sci. U.S.A. 70, 3324–3328 (1973).

    Article  ADS  CAS  Google Scholar 

  19. Knudson, A. G. & Strong, L. C. J. natn. Cancer Inst. 48, 313–324 (1972).

    Google Scholar 

  20. Dryja, T. P. et al. New Engl. J. Med. 310, 550–553 (1984).

    Article  CAS  Google Scholar 

  21. Burton, K. Biochem. J. 62, 315–323 (1956).

    Article  CAS  Google Scholar 

  22. Southern, E. M. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  Google Scholar 

  23. Wahl, G. M., Stern, M. & Stark, G. R. Proc. natn. Acad. Sci. U.S.A. 76, 3683–3687 (1979).

    Article  ADS  CAS  Google Scholar 

  24. Shih, C. & Weinberg, R. A. Cell 29, 161–167 (1982).

    Article  CAS  Google Scholar 

  25. Rotwein, P. S. et al. New Engl. J. Med. 308, 65–71 (1983).

    Article  CAS  Google Scholar 

  26. Feinberg, A. P. & Vogelstein, B. Analyt. Biochem. 132, 6–13 (1983).

    Article  CAS  Google Scholar 

  27. Feinberg, A. P. & Vogelstein, B. Analyt. Biochem. 137, 266–267 (1984).

    Article  CAS  Google Scholar 

  28. Peden, K., Mounts, P. & Hayward, G. S. Cell 31, 71–80 (1982).

    Article  CAS  Google Scholar 

  29. Swanstrom, R. & Shank, P. Analyt. Biochem. 86, 184–192 (1978).

    Article  CAS  Google Scholar 

  30. Cavenee, W., Leach, R., Mohandas, T., Pearson, P. & White, R. Am. J. hum. Genet. 36, 10–24 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Prochownik, E. V. et al. New Engl. J. Med. 308, 1549–1552 (1983).

    Article  CAS  Google Scholar 

  32. Robbins, S. L., Cotran, R. S. & Kumar, V., Pathologic Basis of Disease 3rd end 1070–1076 (Saunders, Philadelphia, 1984).

    Google Scholar 

  33. Fearon, E. R. et al. Hum. Genet. 70, 207–210 (1985).

    Article  CAS  Google Scholar 

  34. Skolnick, M. A., Willard, H. F. & Menlove, L. A. Cytogenet. Cell Genet. 37, 210–273 (1984).

    Article  CAS  Google Scholar 

  35. Francomano, C., Nunez, A. M., Yamada, Y. & Phillips, J. A. Am. J. hum. Genet. 37S 404 (1984).

    Google Scholar 

  36. Phillips, J. A. et al. J. clin. invest. 70, 489–495 (1982).

    Article  Google Scholar 

Download references

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Fearon, E., Feinberg, A., Hamilton, S. et al. Loss of genes on the short arm of chromosome 11 in bladder cancer. Nature 318, 377–380 (1985). https://doi.org/10.1038/318377a0

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