Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins

Abstract

HERPESVIRUS saimiri (HVS) is a T-lymphotropic gammaherpes-virus which establishes asymptomatic infections in its natural host the squirrel monkey (Saimiri sciureus), but which causes fatal lymphoproliferative diseases in other New World primates1. Sequencing studies show HVS is closely related to the human B-lymphotropic gammaherpesvirus Epstein-Barr virus (EBV)2–4. However, despite the general collinearity between the genomes of HVS and EBV, HVS contains genes not found in EBV or in the genomes of any of the other sequenced herpesviruses5–8. We have identified two genes, occurring in a region of divergence between HVS and EBV, that have cellular homologues. One of these, ECRF3, is homologous to the genes encoding the human cytomegalovirus (HCMV) and cellular G protein-coupled receptor family of proteins9. The other HVS gene, ECLF2, is homologous to the genes encoding cellular cyclins and to our knowledge is the first reported example of a viral cyclin. The presence of G protein-coupled receptor and cyclin homologues in HVS suggests that these genes may be important in the regulation of viral and cellular processes during productive and/or latent infection of host cells, and in particular may be of relevance in the transformation and rapid proliferation of T cells during HVS infections of hosts susceptible to HVS-induced lymphoproliferative diseases.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Fleckenstein, B. & Desrosiers, R. C. in The Herpesviruses Vol. 1, 253–332 (ed. Roizman, B.) (Plenum, New York, 1982).

    Book  Google Scholar 

  2. Cameron, K. R. et al. J. Virol. 61, 2063–2070 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Gompels, U. A., Craxton, M. A. & Honess, R. W. J. Virol. 62, 757–767 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Nicholas, J., Coles, L. S., Newman, C. & Honess, R. W. J. Virol. 65, 2457–2466 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Honess, R. W. et al. Proc. natn. Acad. Sci. U.S.A. 83, 3604–3608 (1986).

    Article  ADS  CAS  Google Scholar 

  6. Trimble, J. J., Murthy, S. C. S., Bakker, A., Grassman, R. & Desrosiers, R. C. Science 239, 1145–1147 (1988).

    Article  ADS  CAS  Google Scholar 

  7. Murthy, S. C. S., Trimble, J. J. & Desrosiers, R. C. J. Virol. 63, 3307–3314 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Nicholas, J., Smith, E. P., Coles, L. & Honess, R. Virology 179, 189–200 (1990).

    Article  CAS  Google Scholar 

  9. Chee, M. S., Satchwell, S. C., Preddie, E., Weston, K. M. & Barrell, B. G. Nature 344, 774–777 (1990).

    Article  ADS  CAS  Google Scholar 

  10. Kozak, M. Nucleic Acids Res. 9, 5233–5252 (1981).

    Article  CAS  Google Scholar 

  11. Devereux, J., Haeberli, P. & Smithies, O. Nucleic Acids Res. 12, 387–395 (1984).

    Article  CAS  Google Scholar 

  12. Nathans, J. A. Rev. Neurosci. 10, 163–194 (1987).

    Article  CAS  Google Scholar 

  13. O'Dowd, B. F., Lefkowitz, R. J. & Caron, M. G. A. Rev. Neurosci. 12, 67–83 (1989).

    Article  CAS  Google Scholar 

  14. Fliesler, S. J. & Basinger, S. F. Proc. natnl. Acad. Sci. U.S.A. 82, 1116–1120 (1985).

    Article  ADS  CAS  Google Scholar 

  15. Karnik, S. S., Sakmar, T. P., Chen, H.-B. & Khorana, H. G. Proc. natn. Acad. Sci. U.S.A. 85, 8459–8463 (1988).

    Article  ADS  CAS  Google Scholar 

  16. Murray, A. W. & Kirschner, M. W. Science 246, 614–621 (1989).

    Article  ADS  CAS  Google Scholar 

  17. Wittenberg, C., Sugimoto, K. & Reed, S. I. Cell 62, 225–237 (1990).

    Article  CAS  Google Scholar 

  18. Matsushime, H., Roussel, M. F., Ashmun, R. A. & Sherr, C. J. Cell 65, 701–713 (1991).

    Article  CAS  Google Scholar 

  19. Xiong, Y., Connolly, T., Futcher, B. & Beach, D. Cell 65, 691–699 (1991).

    Article  CAS  Google Scholar 

  20. Minshull, J., Golsteyn, R., Hill, C. S. & Hunt, T. EMBO J. 9, 2865–2875 (1990).

    Article  CAS  Google Scholar 

  21. Swenson, K. I., Farrell, K. M. & Ruderman, J. V. Cell 47, 861–870 (1986).

    Article  CAS  Google Scholar 

  22. Draetta, G. et al. Cell 56, 829–838 (1989).

    Article  CAS  Google Scholar 

  23. Julius, D., Livelli, T. J., Jessell, T. M. & Axel, R. Science 244, 1057–1062 (1989).

    Article  ADS  CAS  Google Scholar 

  24. Young, D., Waitches, G., Birchmeier, C., Fasano, O. & Wigler; M. Cell 45, 711–719 (1986).

    Article  CAS  Google Scholar 

  25. Jackson, T. R., Blair, L. A. C., Marshall, J., Goerdert, M. & Hanley, M. R. Nature 335, 437–440 (1988).

    Article  ADS  CAS  Google Scholar 

  26. Wang, J., Chenivesse, X., Henglein, B. & Bréchot, C. Nature 343, 555–557 (1990).

    Article  ADS  CAS  Google Scholar 

  27. Motokura, T. et al. Nature 350, 512–515 (1991).

    Article  ADS  CAS  Google Scholar 

  28. Mudryj, M. et al. Cell 65, 1243–1253 (1991).

    Article  CAS  Google Scholar 

  29. Bandara, L. R., Adamczewski, J. P., Hunt, T. & La Thangue, N. B. Nature 352, 249–251 (1991).

    Article  ADS  CAS  Google Scholar 

  30. Mudryj, M., Hiebert, S. W. & Nevins, J. R. EMBO J. 9, 2179–2184 (1990).

    Article  CAS  Google Scholar 

  31. Fargin, A. et al. Nature 335, 358–360 (1988).

    Article  ADS  CAS  Google Scholar 

  32. Nathans, J. & Hogness, D. S. Cell 34, 807–814 (1983).

    Article  CAS  Google Scholar 

  33. Needleman, S. B. & Wunsch, C. D. J. molec. Biol. 48, 444–453 (1970).

    Article  Google Scholar 

  34. Lehner, C. F. & O'Farrell, P. H. Cell 56, 957–968 (1989).

    Article  CAS  Google Scholar 

  35. Lehner, C. F. & O'Farrell, P. H. Cell 61, 535–547 (1990).

    Article  CAS  Google Scholar 

  36. Bankier, A. T. & Barren, B. G. in Techniques in the Life Sciences Vol. B5 (ed. Flavell, R. A.) 1–33 (Elsevier, Amsterdam, 1983).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nicholas, J., Cameron, K. & Honess, R. Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins. Nature 355, 362–365 (1992). https://doi.org/10.1038/355362a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/355362a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing