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Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

Nature volume 364, pages 33–39 (1993)Cite this article

Abstract

The three-dimensional structure of the class II histocompatibility glycoprotein HLA-DR1 from human B-cell membranes has been determined by X-ray crystallography and is similar to that of class I HLA. Peptides are bound in an extended conformation that projects from both ends of an 'open-ended' antigen-binding groove. A prominent non-polar pocket into which an 'anchoring' peptide side chain fits is near one end of the binding groove. A dimer of the class II αβ heterodimers is seen in the crystal forms of HLA-DR1, suggesting class II HLA dimerization as a mechanism for initiating the cytoplasmic signalling events in T-cell activation.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138, USA

    Jerry H. Brown, Theodore S. Jardetzky, Joan C. Gorga, Lawrence J. Stern, Robert G. Urban, Jack L. Strominger & Don C. Wiley

  2. Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138, USA

    Jerry H. Brown, Lawrence J. Stern & Don C. Wiley

  3. Department of Pediatrics, Children's Hospital of Pittsburgh, 6130 Ranges Research Building, 3705 Fifth Avenue, Pittsburgh, Pennsylvania, 15213, USA

    Joan C. Gorga

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Brown, J., Jardetzky, T., Gorga, J. et al. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364, 33–39 (1993). https://doi.org/10.1038/364033a0

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