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A genome-wide search for human type 1 diabetes susceptibility genes

Nature volume 371, pages 130–136 (1994)Cite this article

Abstract

We have searched the human genome for genes that predispose to type 1 (insulin-dependent) diabetes mellitus using semi-automated fluorescence-based technology and linkage analysis. In addition to IDDM1 (in the major histocompatibility complex on chromosome 6p21) and IDDM2 (in the insulin gene region on chromosome llpl5), eighteen different chromosome regions showed some positive evidence of linkage to disease. Linkages to chromosomes llq (IDDM4) and 6q (IDDM5) were confirmed by replication, and chromosome 18 may encode a fifth disease locus. There are probably no genes with large effects aside from IDDM1. Therefore polygenic inheritance is indicated, with a major locus at the major histocompatibility complex.

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Author information

Author notes

  1. Beth R. Rowe, Anthony H. Barnett and Stephen C. Bain: Department of Medicine/Diabetes/Endocrinology, University of Birmingham, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK

  2. Martin Farrall: MRC Clinical Research Centre, Hammersmith Hospital, Du Cane Road, London W12 ONN, and The Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Road, Oxford 0X3 7BN, UK

Authors and Affiliations

  1. Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford, 0X3 9DU

    June L. Davies, Yoshihiko Kawaguchi, Simon T. Bennett, James B. Copeman, Heather J. Cordell, Lynn E. Pritchard, Peter W. Reed, Stephen C. L. Gough, Suzanne C. Jenkins, Sheila M. Palmer, Karen M. Balfour, Beth R. Rowe, Martin Farrall, Anthony H. Barnett, Stephen C. Bain & John A. Todd

  2. The Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Road, Oxford, 0X3 7BN, UK

    June L. Davies, Yoshihiko Kawaguchi, Simon T. Bennett, James B. Copeman, Heather J. Cordell, Lynn E. Pritchard, Peter W. Reed, Stephen C. L. Gough, Suzanne C. Jenkins, Sheila M. Palmer, Karen M. Balfour, Beth R. Rowe, Martin Farrall, Anthony H. Barnett, Stephen C. Bain & John A. Todd

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Davies, J., Kawaguchi, Y., Bennett, S. et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371, 130–136 (1994). https://doi.org/10.1038/371130a0

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