Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Short Report
  • Published:

Oligomerization of p53 is necessary to inhibit its transcriptional transactivation property at high protein concentration

Oncogene volume 16, pages 2413–2418 (1998)Cite this article

Abstract

We have previously shown that transactivation by tumor suppressor protein p53 can be inhibited in vivo at elevated protein concentrations. In this study we characterize the structural requirements of this function. We show that oligomerization domain of p53 is involved in loss of transactivation at high protein concentrations: mutants not able to oligomerize are neither able to suppress transactivation, although these transactivating properties can be untouched.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Institute of Molecular and Cell Biology, Estonian Biocentre, Tartu University, Riia 23, Tartu, EE2400, Estonia

    Arnold Kristjuhan, Viljar Jaks, Ilvi Rimm, Tiia Tooming & Toivo Maimets

Authors
  1. Arnold Kristjuhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Viljar Jaks
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ilvi Rimm
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tiia Tooming
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Toivo Maimets
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kristjuhan, A., Jaks, V., Rimm, I. et al. Oligomerization of p53 is necessary to inhibit its transcriptional transactivation property at high protein concentration. Oncogene 16, 2413–2418 (1998). https://doi.org/10.1038/sj.onc.1201749

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1201749

Keywords

This article is cited by

Search

Advanced search

Quick links