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The Human Papillomavirus E6 protein and its contribution to malignant progression

Oncogene volume 20, pages 7874–7887 (2001)Cite this article

Abstract

The Human Papillomavirus (HPV) E6 protein is one of three oncoproteins encoded by the virus. It has long been recognized as a potent oncogene and is intimately associated with the events that result in the malignant conversion of virally infected cells. In order to understand the mechanisms by which E6 contributes to the development of human malignancy many laboratories have focused their attention on identifying the cellular proteins with which E6 interacts. In this review we discuss these interactions in the light of their respective contributions to the malignant progression of HPV transformed cells.

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Acknowledgements

We are grateful to C Meyers, D Pim and M Thomas for allowing us to cite their unpublished work. We are also grateful to M Thomas for valuable comments on the manuscript. L Banks gratefully acknowledges research support provided by the Associazione Italiana per la Ricerca sul Cancro.

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Mantovani, F., Banks, L. The Human Papillomavirus E6 protein and its contribution to malignant progression. Oncogene 20, 7874–7887 (2001). https://doi.org/10.1038/sj.onc.1204869

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