Regular ArticleCharacteristic Growth of Human Choriocarcinoma Xenografts in Nude Mice
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Cited by (19)
Gene expression profile of a newly established choriocarcinoma cell line, iC<sup>3</sup>-1, compared to existing choriocarcinoma cell lines and normal placenta
2013, PlacentaCitation Excerpt :Based on the characteristics of each these cell lines, BeWo cells are commonly used to study processes underlying syncytialization, adhesion and migration, while JAR and JEG3 cells are used to study molecular mechanisms underlying proliferation and invasive potential, respectively [2–5]. However, these cell lines do not generate tumors that are pathologically similar to human choriocarcinoma, which consists of two distinct types of cells: multinucleated syncytiotrophoblasts and mononuclear cytotrophoblasts [6,7]. To address this problem, we established a new choriocarcinoma cell line, induced choriocarcinoma cell-1 (iC3-1), that produces tumors consisting of the two types of cells and mimics the clinical pathology [8].
Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12
2011, American Journal of PathologyCitation Excerpt :BeWo, JAR, and JEG3 are commonly used choriocarcinoma cell lines derived from human spontaneous choriocarcinoma. However, BeWo cells are nontumorigenic,22 and JAR and JEG3 cells do not generate tumors that are pathologically similar to human choriocarcinoma.22 Here, we have achieved the generation of a choriocarcinoma mouse model by overexpressing oncogenic HRASV12 in the human immortalized normal trophoblastic cell line, HTR8/SVneo.
Down-regulation of HLA-G boosted natural killer cell-mediated cytolysis in JEG-3 cells cultured in vitro
2008, Fertility and SterilityCitation Excerpt :Functions of HLA-G include inhibition of [1] allogenic proliferation of T cells, [2] NK cell cytotoxicity, [3] antigen-specific T-cell cytotoxicity, and [4] induction of apoptosis by activated CD8+ T cells and NK cells. In addition to its immunoprotecting role, HLA-G may play a role in remodeling of spiral arteries and establishment of a hemochorial placenta (18–20). In the mucosal decidua tissues of the uterus, NK cells are the most abundant lymphocytes, representing up to 95% (21).
Modeling Trophoblast Differentiation using Equine Chorionic Girdle Vesicles
2008, PlacentaCitation Excerpt :Similar to our studies, trophoblast cells were shown to remain viable for at least 30 days [29]. The human malignant trophoblast tumor cell line Jeg-3 choriocarcinoma cells has also been shown to grow in athymic mice [30]. The ability of athymic and/or alymphoid mice to tolerate placental grafts and grafts of transformed tumor cells is not surprising given the significantly compromised immune system of these mice.
Chapter 12 Placental Remodeling of the Uterine Vasculature
2008, Methods in EnzymologyCitation Excerpt :Histological analyses allowed quantitative estimates of invasion that were made by calculating the distance between the implanted villi and the outer perimeter of placental cells that had invaded murine tissues. Another group reported an alternative model for investigating CTB invasive behavior (Grummer et al., 1999). Rather than studying primary CTBs or explants isolated from placental tissue, this group used the tumorigenic properties of the Jeg‐3 human choriocarcinoma cell line, which was injected subcutaneously in the murine flank.
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