Regular ArticleConnexin Expression Patterns in Human Trophoblast Cells during Placental Development
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Cited by (43)
The role of junctional adhesion molecule-C in trophoblast differentiation and function during normal pregnancy and preeclampsia
2022, PlacentaCitation Excerpt :If the expression of adhesion molecules is dysregulated, pregnancy complications such as PE may take place [5,9,10]. Adhesion molecules such as Connexin and Protocadherin-12 participate in the pathophysiology of PE by contributing to a reduced invasive property of trophoblasts [11,12]. Junctional adhesion molecules (JAMs) belong to the immunoglobulin superfamily and play pivotal roles in maintaining the tight junction integrity of epithelial cells and regulating cell migration, homing, and proliferation [13–15].
Gap junctional connexin messenger RNA expression in the ovine uterus and placenta: effects of estradiol-17β-treatment, early pregnancy stages, and embryo origin
2017, Domestic Animal EndocrinologyCitation Excerpt :Connexins have been implicated in the regulation of cellular metabolism and the coordination of cellular functions during growth and differentiation of organs and tissues with or without formation of the gap junctional channel [1–3]. Gap junctional channels and Cx messenger RNA (mRNA) and proteins have been detected in uterine and placental tissues in several species [4–14]. Thus, expression of Cx mRNA and proteins and cell-cell communication mediated through gap junctional channels are likely involved in the regulation of utero-placental and fetal function and growth.
Review: The ADAM metalloproteinases - Novel regulators of trophoblast invasion?
2014, PlacentaCitation Excerpt :The tendency to reorganize in epithelial structures might also reflect the reverse process of epithelial to mesenchymal transition (EMT) termed mesenchymal to epithelial transition, which is believed to play an important role in the formation of transient epithelia during embryonic development [8]. Indeed, various epithelial markers such as E-cadherin are downregulated during EVT differentiation [9], whereas iCTB aggregates re-express E-cadherin [7] or certain connexins (Cx) such as Cx40 [10]. As indicated above, invasive iCTBs connect to spiral arteries and induce, in concert with uterine natural killer (uNK) cells and macrophages, the transformation of spiral arteries [11].
Effect of high-frequency electromagnetic fields on trophoblastic connexins
2009, Reproductive Toxicology
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To whom correspondence should be addressed at: Institute of Anatomy, Medical School, University of Essen, D-45122 Essen Hufelandstr. 55, Germany.