REVIEWDoes the GH–IGF axis play a role in cancer pathogenesis?
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Cited by (149)
Physiologic Growth Hormone–Replacement Therapy and Craniopharyngioma Recurrence in Pediatric Patients: A Meta-Analysis
2018, World NeurosurgeryCitation Excerpt :Both growth hormone and IGF-1 have well-established mitogenic and antiapoptotic properties.25-27 Therefore, these agents have previously been proposed to play a considerable role in carcinogenesis and tumor growth, with several groups demonstrating an association between serum IGF-1 levels and prostate, breast, and colon cancer risks.28-30 In addition, the increased risk of developing certain malignancies as a result of elevated growth hormone are consistent with observations in patients with acromegaly who have elevated levels of circulating growth hormone and IGF-1.
Insulin-like growth factor binding-protein-3 (IGFBP-3)
2015, Best Practice and Research: Clinical Endocrinology and MetabolismDisorders of growth hormone/insulin-like growth factor secretion and action
2014, Pediatric Endocrinology: Fourth EditionIncreased genome instability and oxidative DNA damage and their association with IGF-1 levels in patients with active acromegaly
2014, Growth Hormone and IGF ResearchCitation Excerpt :It is reported that acromegaly patients have an increased risk of developing both benign and malignant tumours, particularly colorectal cancer, and possibly other cancers such as breast, prostate, thyroid and haematological malignancies [7,8]. The aetiology of these cancers remains uncertain, but they may be related to both growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels [9–14]. However, some epidemiological studies report conflicting findings on cancer risk in acromegaly [15,16].
GH and IGF1 in cancer therapy resistance
2023, Endocrine-Related Cancer