CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation

Immunol Today. 1992 Nov;13(11):431-3. doi: 10.1016/0167-5699(92)90068-I.

Abstract

The discovery of CD40 and its ligand, gp39, have created new perspectives on the activation of resting B cells by TH cells. Here, Randolph Noelle, Jeffrey Ledbetter and Alejandro Aruffo describe how these molecules were characterized and, from recent findings, examine their relevance to immune activation.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD / physiology*
  • Antigens, Differentiation, B-Lymphocyte / physiology*
  • B-Lymphocytes / immunology*
  • CD40 Antigens
  • CD40 Ligand
  • DNA / genetics
  • Humans
  • Ligands
  • Lymphocyte Activation*
  • Lymphocyte Cooperation*
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / physiology*
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Mice
  • Recombinant Fusion Proteins / pharmacology
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • T-Lymphocytes, Helper-Inducer / immunology*

Substances

  • Antigens, CD
  • Antigens, Differentiation, B-Lymphocyte
  • CD40 Antigens
  • Ligands
  • Membrane Glycoproteins
  • Membrane Proteins
  • Recombinant Fusion Proteins
  • CD40 Ligand
  • DNA