Abstract
The discovery of CD40 and its ligand, gp39, have created new perspectives on the activation of resting B cells by TH cells. Here, Randolph Noelle, Jeffrey Ledbetter and Alejandro Aruffo describe how these molecules were characterized and, from recent findings, examine their relevance to immune activation.
MeSH terms
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Animals
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Antigens, CD / physiology*
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Antigens, Differentiation, B-Lymphocyte / physiology*
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B-Lymphocytes / immunology*
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CD40 Antigens
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CD40 Ligand
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DNA / genetics
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Humans
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Ligands
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Lymphocyte Activation*
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Lymphocyte Cooperation*
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / physiology*
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Membrane Proteins / genetics
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Membrane Proteins / physiology*
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Mice
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Recombinant Fusion Proteins / pharmacology
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Sequence Homology, Amino Acid
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Signal Transduction
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T-Lymphocytes, Helper-Inducer / immunology*
Substances
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Antigens, CD
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Antigens, Differentiation, B-Lymphocyte
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CD40 Antigens
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Ligands
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Membrane Glycoproteins
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Membrane Proteins
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Recombinant Fusion Proteins
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CD40 Ligand
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DNA