Abstract
The specificity of the immune response is determined by the interaction between the B-cell receptor (BCR) and its cognate structure, antigen. Recent studies have provided considerable insight into the compartmentalization of function within this extremely versatile hetero-oligomeric receptor complex. In this article, Christopher Pleiman, Daniele D'Ambrosio and John Cambier consolidate new findings regarding BCR structure and signal transduction.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Enzyme Precursors / immunology
-
Humans
-
Intracellular Signaling Peptides and Proteins
-
Molecular Sequence Data
-
Protein-Tyrosine Kinases / immunology
-
Receptors, Antigen, B-Cell / chemistry
-
Receptors, Antigen, B-Cell / immunology*
-
Signal Transduction / immunology*
-
Syk Kinase
Substances
-
Enzyme Precursors
-
Intracellular Signaling Peptides and Proteins
-
Receptors, Antigen, B-Cell
-
Protein-Tyrosine Kinases
-
SYK protein, human
-
Syk Kinase