A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers

Nat Genet. 1993 Oct;5(2):151-7. doi: 10.1038/ng1093-151.

Abstract

From chromosomal region 17q21.3, where a tumour suppressor gene(s) for breast and ovarian cancers is thought to be present, we have isolated a novel gene from a cosmid clone that revealed somatic rearrangements in two breast cancers. The gene (MDC) encodes a 524-amino acid metalloprotease-like, disintegrin-like and cysteine-rich protein with sequence similarity to members of the snake-venom metalloprotease/disintegrin family and guinea-pig sperm-surface protein PH-30. These proteins have been implicated in cell-cell or cell-extracellular matrix interactions. Rearrangements in both tumours involve multiple exons and disrupt the coding region of the new MDC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Breast Neoplasms / genetics*
  • Cell Line
  • Chromosomes, Human, Pair 17*
  • DNA, Complementary
  • Disintegrins
  • Gene Rearrangement*
  • Humans
  • Metalloendopeptidases / genetics*
  • Molecular Sequence Data
  • Peptides / genetics*
  • Sequence Homology, Amino Acid
  • Tumor Cells, Cultured
  • Venoms / genetics*

Substances

  • DNA, Complementary
  • Disintegrins
  • Peptides
  • Venoms
  • Metalloendopeptidases

Associated data

  • GENBANK/D17390