Abstract
Like other herpesviruses, Epstein-Barr virus persists in its host through its ability to establish a latent infection that periodically reactivates. Latent membrane protein 2A (LMP2A) regulates reactivation from latency by interfering with normal B cell signal transduction processes, and may define a new class of regulators of herpesvirus latency.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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B-Lymphocytes / immunology*
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Gene Expression Regulation, Viral
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Genes, Viral / genetics*
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Herpesviridae Infections / immunology*
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Herpesviridae Infections / virology*
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Herpesvirus 4, Human / immunology*
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Herpesvirus 4, Human / physiology
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Humans
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Molecular Sequence Data
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Signal Transduction
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Viral Matrix Proteins / genetics
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Viral Matrix Proteins / immunology*
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Virus Latency / physiology*
Substances
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EBV-associated membrane antigen, Epstein-Barr virus
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Viral Matrix Proteins