Abstract
TFIIH is by far the most complex of the basal RNA polymerase II transcription factors. It is a protein kinase, a bi-directional DNA helicase and is essential for both transcription and nucleotide excision repair (NER). Furthermore, the factor can activate cyclin-dependent kinases and so might play a role in cell-cycle regulation. The recent elucidation of the subunit composition of TFIIH has shown an extraordinary conservation of its structure from yeast to human.
MeSH terms
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Adenosine Triphosphate / metabolism
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Animals
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Binding Sites
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Cyclin-Dependent Kinases / metabolism
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DNA Helicases / metabolism
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DNA Repair*
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Enzyme Activation
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Humans
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Phosphorylation
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RNA Polymerase II / metabolism
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Transcription Factor TFIIH
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Transcription Factors / chemistry
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transcription Factors / physiology*
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Transcription Factors, TFII*
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Transcription, Genetic*
Substances
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Transcription Factors
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Transcription Factors, TFII
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transcription factor TFIIE
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Transcription Factor TFIIH
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Adenosine Triphosphate
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Cyclin-Dependent Kinases
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RNA Polymerase II
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DNA Helicases