Abstract
A new member of the NCAM family mapping to 3p12 has been isolated and predicted to be arranged in five immunoglobulin-like domains and three fibronectin-like domains which are particularly homologous to L1. There is a transmembrane domain and a long cytoplasmic region with no detectable homology to other sequences. Although less closely related to DCC, another family member, both share a loop of positively charged amino acids within the first immunoglobulin domain, unique to these two members of this very large gene family. Preliminary studies of expression in mouse embryos support an inferred role in neural development, but the observation of widespread gene expression in adult human tissues indicates that this protein has additional functions to those performed in neural cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Adhesion Molecules / genetics
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Chromosomes, Human, Pair 3 / genetics
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DCC Receptor
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Embryo, Mammalian
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Gene Expression Regulation, Developmental
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Genes, Tumor Suppressor*
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Humans
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Leukocyte L1 Antigen Complex
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Membrane Glycoproteins / genetics
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Mice
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Molecular Sequence Data
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Nerve Tissue Proteins / biosynthesis
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Nerve Tissue Proteins / genetics*
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Neural Cell Adhesion Molecules / genetics*
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Neurons / metabolism*
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Organ Specificity / genetics
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Receptors, Cell Surface
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Receptors, Immunologic
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Roundabout Proteins
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Sequence Homology, Amino Acid
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Tumor Cells, Cultured
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Tumor Suppressor Proteins*
Substances
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Cell Adhesion Molecules
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DCC Receptor
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DCC protein, human
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Dcc protein, mouse
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Leukocyte L1 Antigen Complex
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Membrane Glycoproteins
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Nerve Tissue Proteins
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Neural Cell Adhesion Molecules
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Receptors, Cell Surface
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Receptors, Immunologic
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Tumor Suppressor Proteins