Abstract
Significant progress has been made in the identification of genes and chromosomal loci associated with several types of motor neuron disease. Of particular interest is recent work on the pathogenic mechanisms underlying these diseases, especially studies in in vitro model systems and in transgenic and gene-targeted mice.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amyotrophic Lateral Sclerosis / genetics
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Amyotrophic Lateral Sclerosis / pathology
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Amyotrophic Lateral Sclerosis / physiopathology
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Animals
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Humans
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Mice
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Mice, Transgenic / genetics
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Motor Neuron Disease / genetics*
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Motor Neuron Disease / pathology
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Motor Neuron Disease / physiopathology
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Muscular Atrophy, Spinal / genetics
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Mutation / physiology
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Paraplegia / genetics
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Superoxide Dismutase / genetics