The COX-2/PGE 2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment
A Greenhough, HJM Smartt, AE Moore… - …, 2009 - academic.oup.com
It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …
Penetration enhancers
AC Williams, BW Barry - Advanced drug delivery reviews, 2012 - Elsevier
One long-standing approach for improving transdermal drug delivery uses penetration
enhancers (also called sorption promoters or accelerants) which penetrate into skin to …
enhancers (also called sorption promoters or accelerants) which penetrate into skin to …
Liposomes and skin: from drug delivery to model membranes
GM El Maghraby, BW Barry, AC Williams - European journal of …, 2008 - Elsevier
The early eighties saw the introduction of liposomes as skin drug delivery systems, initially
promoted primarily for localised effects with minimal systemic delivery. Subsequently, a …
promoted primarily for localised effects with minimal systemic delivery. Subsequently, a …
Chronic Parkinsonism secondary to intravenous injection of meperidine analogues
GC Davis, AC Williams, SP Markey, MH Ebert… - Psychiatry …, 1979 - Elsevier
Abstract Abuse of 4-propyloxy-4-phenyl-N-methylpiperidine, a meperidine congener,
produced parkinsonism in a 23-year-old man. Unlike other drug-induced motor …
produced parkinsonism in a 23-year-old man. Unlike other drug-induced motor …
Why is chitosan mucoadhesive?
IA Sogias, AC Williams, VV Khutoryanskiy - Biomacromolecules, 2008 - ACS Publications
Chitosan is a biocompatible and biodegradable amino polysaccharide, which is soluble in
aqueous solutions at pH< 6.5. It has been widely used for developing drug delivery systems …
aqueous solutions at pH< 6.5. It has been widely used for developing drug delivery systems …
Solubility parameters as predictors of miscibility in solid dispersions
DJ Greenhalgh, AC Williams, P Timmins… - Journal of pharmaceutical …, 1999 - Elsevier
This paper reports interactions and possible incompatibilities in solid dispersions of
hydrophobic drugs with hydrophilic carriers, with solubility parameters employed as a …
hydrophobic drugs with hydrophilic carriers, with solubility parameters employed as a …
Terpenes and the lipid–protein–partitioning theory of skin penetration enhancement
AC Williams, BW Barry - Pharmaceutical research, 1991 - Springer
A series of terpenes has been assessed as skin penetration enhancers towards the model
polar penetrant 5-fluorouracil (5-FU). Cyclic terpenes were selected from the chemical …
polar penetrant 5-fluorouracil (5-FU). Cyclic terpenes were selected from the chemical …
Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia
A Kaidi, AC Williams, C Paraskeva - Nature cell biology, 2007 - nature.com
Aberrant activation of β-catenin promotes cell proliferation and initiates colorectal
tumorigenesis,. However, the expansion of tumours and the inadequacy of their local …
tumorigenesis,. However, the expansion of tumours and the inadequacy of their local …
Regulatory T cells promote myelin regeneration in the central nervous system
Y Dombrowski, T O'hagan, M Dittmer, R Penalva… - Nature …, 2017 - nature.com
Regeneration of CNS myelin involves differentiation of oligodendrocytes from
oligodendrocyte progenitor cells. In multiple sclerosis, remyelination can fail despite …
oligodendrocyte progenitor cells. In multiple sclerosis, remyelination can fail despite …
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss
of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT …
of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT …