Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and
lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic …

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is
characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is …

Loss of function of the E-cadherin gene (CDH1) has been linked with diffuse gastric cancer
susceptibility, and germline inactivating mutations in CDH1 characterise the hereditary …

Hereditary diffuse gastric cancer (HDGC) is the only known cancer syndrome that is
dominated by gastric adenocarcinoma. HDGC is caused by germline mutation of the CDH1 …

Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome defined by germline
mutation of the E-cadherin gene (CDH-1). The cumulative risk for advanced gastric cancer in …

Objectives: To develop a reproducible animal model mimicking a novel 2-staged
hepatectomy (ALPPS: Associating Liver Partition and Portal Vein Ligation for Staged …

The importance of loss of the cell-cell adhesion molecule E-cadherin (encoded by CDH1) to
tumor progression is well established. However, CDH1 germ-line mutations predispose to …

The initial development of diffuse gastric cancer (DGC) is poorly understood. The study of E-
cadherin (CDH1) germ line mutation carriers predisposed to DGC provides a rare …

BACKGROUND & AIMS: Extended liver resection leads to hepatic failure because of a small
remnant liver volume. Excessive parenchymal damage has been proposed as the principal …

The majority of hepatocellular carcinoma occurs over pre-existing chronic liver diseases that
share cirrhosis as an endpoint. In the last decade, a strong association between lifestyle and …