CELL CYCLE CONTROL IN ANIMALS 443 established in many cases. Nonetheless, the
phosphorylation of nuclear lamins to promote nuclear disassembly (25, 31, 38-40), and the …

Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging
agents. These agents can either be exogenous or formed within cells. Environmental DNA …

Unicellular organisms respond to the presence of DNA lesions by activating cell cycle
checkpoint and repair mechanisms, while multicellular animals have acquired the further …

In the fission yeast S. pombe, the M,= 34 kd product of the cdc2+ gene (~ 34~ d~ 2) is a
protein kinase that controls entry into mitosis. In Xenopus oocytes and other cells, maturation …

MicroRNAs (miRNAs) are versatile regulators of gene expression in higher eukaryotes. In
order to silence many different mRNAs in a precise manner, miRNA stability and efficacy is …

The p34cdc2 protein kinase is a conserved regulator of the eukaryotic cell cycle. Here we
show that residues Thr14 and Tyr15 of mouse p34cdc2 become phosphorylated as mouse …

Abstract 'Checkpoint'controls arrest the cell cycle after DNA damage, allowing repair to take
place before mutations can be perpetuated. In multicellular organisms, DNA damage can …

Both end structures of eukaryotic mRNAs, namely the 5′ cap and 3′ poly (A) tail, are
necessary for transcript stability, and loss of either is sufficient to stimulate decay. mRNA …

The addition of poly (A) tails to eukaryotic nuclear mRNAs promotes their stability, export to
the cytoplasm and translation. Subsequently, the balance between exonucleolytic …

Nuclear poly (A) polymerase (PAP) polyadenylates nascent mRNAs, promoting their nuclear
export, stability, and translation, while the related cytoplasmic polymerase GLD-2 activates …