User profiles for "author:D Kelleher"

Dermot Kelleher

- Verified email at ubc.ca - Cited by 25785

Daniel J Kelleher

- Verified email at umassmed.edu - Cited by 4807

Statistical methods for analysis of high-throughput RNA interference screens

…, J Santoyo-Lopez, DJ Dunican, A Long, D Kelleher… - Nature …, 2009 - nature.com
RNA interference (RNAi) has become a powerful technique for reverse genetics and drug
discovery, and in both of these areas large-scale high-throughput RNAi screens are …

Oxygenation status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy

P Vaupel, DK Kelleher, M Höckel - Seminars in oncology, 2001 - Elsevier
Hypoxic areas are a characteristic property of solid tumors. Hypoxia results from an
imbalance between the supply and consumption of oxygen. Major pathogenetic …

An evolving view of the eukaryotic oligosaccharyltransferase

DJ Kelleher, R Gilmore - Glycobiology, 2006 - academic.oup.com
Asparagine-linked glycosylation (ALG) is one of the most common protein modification
reactions in eukaryotic cells, as many proteins that are translocated across or integrated into …

Multiple common variants for celiac disease influencing immune gene expression

…, RHJ Houwen, SE Hunt, K Kaukinen, D Kelleher… - Nature …, 2010 - nature.com
We performed a second-generation genome-wide association study of 4,533 individuals
with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs …

Newly identified genetic risk variants for celiac disease related to the immune response

…, FM Stevens, C O'Morain, NP Kennedy, D Kelleher… - Nature …, 2008 - nature.com
Our genome-wide association study of celiac disease previously identified risk variants in
the IL2–IL21 region. To identify additional risk variants, we genotyped 1,020 of the most …

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

…, GKT Holmes, C Feighery, D Jewell, D Kelleher… - Nature …, 2007 - nature.com
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422
controls. Outside the HLA region, the most significant finding (rs13119723; P= 2.0× 10− 7) …

International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease

…, A Dispenzieri, A Fosså, D Kelleher… - Blood, The Journal …, 2017 - ashpublications.org
Abstract Human herpesvirus-8 (HHV-8)–negative, idiopathic multicentric Castleman disease
(iMCD) is a rare and life-threatening disorder involving systemic inflammatory symptoms …

Detailed study of the Stark broadening of Balmer lines in a high-density plasma

WL Wiese, DE Kelleher, DR Paquette - Physical Review A, 1972 - APS
The Stark-broadened profiles of the Balmer lines H α, H β, H γ, and H δ, have been
measured in a high-current, wall-stabilized arc operated in hydrogen. Temperatures and …

St John's wort increases expression of P‐glycoprotein: implications for drug interactions

M Hennessy, D Kelleher, JP Spiers… - British journal of …, 2002 - Wiley Online Library
Aims St John's Wort (SJW) is widely used in the treatment of depression but concerns have
been raised about its potential to interact with other drugs. Co‐administration with SJW has …

Nanodrug applications in photodynamic therapy

E Paszko, C Ehrhardt, MO Senge, DP Kelleher… - Photodiagnosis and …, 2011 - Elsevier
Photodynamic therapy (PDT) has developed over last century and is now becoming a more
widely used medical tool having gained regulatory approval for the treatment of various …