Dengue viral infections are one of the most important mosquito borne diseases in the world.
They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue …

The dengue virus can infect many cell types and cause diverse clinical and pathological
effects. We describe clinical and experimental observations that suggest that liver …

Endothelial dysfunction leading to vascular leak is the hallmark of severe dengue. Vascular
leak typically becomes clinically evident 3–6 days after the onset of illness, which is known …

Background Liver involvement in acute dengue infection is frequently observed and
sometimes leads to acute liver failure, with fatal outcomes. Many factors are thought to …

Background Early detection of complications significantly reduces dengue associated
mortality and morbidity. We set out to determine if the NS1 rapid antigen detection test could …

BACKGROUND: Dengue is a major public health problem in several countries. Few reports
document presentations and outcomes of dengue during pregnancy. In many endemic …

Background: Recent years have seen an increase in dengue infections among adults in Sri
Lanka, with similar trends seen in many other countries. Data on the natural history and …

Background The occurrence of dengue haemorrhagic fever (DHF) is thought to result from a
complex interplay between the virus, host genetics and host immune factors. Existing …

Background Although plasma leakage is the hallmark of severe dengue infections, the
factors that cause increased vascular permeability have not been identified. As platelet …

Both dengue NS1 antigen and serum interleukin (IL)-10 levels have been shown to
associate with severe clinical disease in acute dengue infection, and IL-10 has also been …