BRAFV600E: Implications for Carcinogenesis and Molecular Therapy
ER Cantwell-Dorris, JJ O'Leary, OM Sheils - Molecular cancer therapeutics, 2011 - AACR
The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)
pathway is frequently mutated in human cancer. This pathway consists of a small GTP …
pathway is frequently mutated in human cancer. This pathway consists of a small GTP …
Circulating tumour cells, their role in metastasis and their clinical utility in lung cancer
Circulating tumour cells (CTCs) have attracted much recent interest in cancer research as a
potential biomarker and as a means of studying the process of metastasis. It has long been …
potential biomarker and as a means of studying the process of metastasis. It has long been …
Microsatellites and PCR genomic analysis
J Koreth, JJ O'LEARY… - The Journal of pathology, 1996 - Wiley Online Library
Microsatellites form a significant proportion of the growing family of repetitive DNA
sequences, widely dispersed in the human genome. Due to their ubiquity, PCR (polymerase …
sequences, widely dispersed in the human genome. Due to their ubiquity, PCR (polymerase …
Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21
The tumor suppressor PDCD4 is a proinflammatory protein that promotes activation of the
transcription factor NF-κB and suppresses interleukin 10 (IL-10). Here we found that mice …
transcription factor NF-κB and suppresses interleukin 10 (IL-10). Here we found that mice …
Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells
C Boshoff, TF Schulz, MM Kennedy, AK Graham… - Nature medicine, 1995 - nature.com
Abstract Kaposi's sarcoma (KS), a vascular tumour that contains characteristic spindle cells
forming slit-like spaces, may have an infectious aetiology. Recently, sequences of a new …
forming slit-like spaces, may have an infectious aetiology. Recently, sequences of a new …
[HTML][HTML] Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap …
Background Archival formalin-fixed paraffin-embedded (FFPE) tissues have limited utility in
applications involving analysis of gene expression due to mRNA degradation and …
applications involving analysis of gene expression due to mRNA degradation and …
Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus
Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, is invariably
present in Kaposi's sarcoma lesions,. KSHV contains several viral oncogenes and …
present in Kaposi's sarcoma lesions,. KSHV contains several viral oncogenes and …
[HTML][HTML] Generation and characterisation of cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature
Introduction Inherent and acquired cisplatin resistance reduces the effectiveness of this
agent in the management of non-small cell lung cancer (NSCLC). Understanding the …
agent in the management of non-small cell lung cancer (NSCLC). Understanding the …
Enterocolitis in Children With Developmental Disorders [RETRACTED]
AJ Wakefield, A Anthony, SH Murch… - Official journal of the …, 2000 - journals.lww.com
OBJECTIVE: Intestinal pathology, ie., ileocolonic lymphoid nodular hyperplasia (LNH) and
mucosal inflammation, has been described in children with developmental disorders. This …
mucosal inflammation, has been described in children with developmental disorders. This …
p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep™ smears
N Murphy, M Ring, AG Killalea, V Uhlmann… - Journal of Clinical …, 2003 - jcp.bmj.com
Aim: To examine the potential of p16INK4A as a biomarker for dysplastic squamous and
glandular cells of the cervix in tissue sections and ThinPrep™ smears. Methods …
glandular cells of the cervix in tissue sections and ThinPrep™ smears. Methods …