The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)
pathway is frequently mutated in human cancer. This pathway consists of a small GTP …

Circulating tumour cells (CTCs) have attracted much recent interest in cancer research as a
potential biomarker and as a means of studying the process of metastasis. It has long been …

Microsatellites form a significant proportion of the growing family of repetitive DNA
sequences, widely dispersed in the human genome. Due to their ubiquity, PCR (polymerase …

The tumor suppressor PDCD4 is a proinflammatory protein that promotes activation of the
transcription factor NF-κB and suppresses interleukin 10 (IL-10). Here we found that mice …

Abstract Kaposi's sarcoma (KS), a vascular tumour that contains characteristic spindle cells
forming slit-like spaces, may have an infectious aetiology. Recently, sequences of a new …

Background Archival formalin-fixed paraffin-embedded (FFPE) tissues have limited utility in
applications involving analysis of gene expression due to mRNA degradation and …

Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, is invariably
present in Kaposi's sarcoma lesions,. KSHV contains several viral oncogenes and …

Introduction Inherent and acquired cisplatin resistance reduces the effectiveness of this
agent in the management of non-small cell lung cancer (NSCLC). Understanding the …

OBJECTIVE: Intestinal pathology, ie., ileocolonic lymphoid nodular hyperplasia (LNH) and
mucosal inflammation, has been described in children with developmental disorders. This …

Aim: To examine the potential of p16INK4A as a biomarker for dysplastic squamous and
glandular cells of the cervix in tissue sections and ThinPrep™ smears. Methods …