User profiles for "author:J W Neal"

Jennifer Watling Neal

Professor of Psychology, Michigan State University
Verified email at msu.edu
Cited by 4182

Dissecting metastasis using preclinical models and methods

JD Hebert, JW Neal, MM Winslow - Nature Reviews Cancer, 2023 - nature.com
Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

AM Newman, SV Bratman, J To, JF Wynne… - Nature medicine, 2014 - nature.com
Circulating tumor DNA (ctDNA) is a promising biomarker for noninvasive assessment of
cancer burden, but existing ctDNA detection methods have insufficient sensitivity or patient …

[HTML][HTML] Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

C Holmes, D Boche, D Wilkinson, G Yadegarfar… - The Lancet, 2008 - thelancet.com
Background Immunisation of patients with Alzheimer's disease with full-length amyloid-β
peptide (Aβ 42) can clear amyloid plaques from the brain. Our aim was to assess the relation …

The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain

MR Griffiths, P Gasque, JW Neal - Journal of Neuropathology & …, 2009 - academic.oup.com
Central nervous system (CNS) tissues contain cells (ie glia and neurons) that have innate
immune functions. These cells express a range of receptors that are capable of detecting …

Integrated digital error suppression for improved detection of circulating tumor DNA

AM Newman, AF Lovejoy, DM Klass, DM Kurtz… - Nature …, 2016 - nature.com
High-throughput sequencing of circulating tumor DNA (ctDNA) promises to facilitate
personalized cancer therapy. However, low quantities of cell-free DNA (cfDNA) in the blood …

Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins

M Griffiths, JW Neal, P Gasque - International review of neurobiology, 2007 - Elsevier
Brain inflammation due to infection, hemorrhage, and aging is associated with activation of
the local innate immune system as expressed by infiltrating cells, resident glial cells, and …

[HTML][HTML] Rociletinib in EGFR-Mutated Non–Small-Cell Lung Cancer

LV Sequist, JC Soria, JW Goldman… - … England Journal of …, 2015 - Mass Medical Soc
Background Non–small-cell lung cancer (NSCLC) with a mutation in the gene encoding
epidermal growth factor receptor (EGFR) is sensitive to approved EGFR inhibitors, but …

Early detection of molecular residual disease in localized lung cancer by circulating tumor DNA profiling

AA Chaudhuri, JJ Chabon, AF Lovejoy, AM Newman… - Cancer discovery, 2017 - AACR
Identifying molecular residual disease (MRD) after treatment of localized lung cancer could
facilitate early intervention and personalization of adjuvant therapies. Here, we apply cancer …

Integrating genomic features for non-invasive early lung cancer detection

JJ Chabon, EG Hamilton, DM Kurtz, MS Esfahani… - Nature, 2020 - nature.com
Radiologic screening of high-risk adults reduces lung-cancer-related mortality,; however, a
small minority of eligible individuals undergo such screening in the United States,. The …

[HTML][HTML] Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients

JJ Chabon, AD Simmons, AF Lovejoy… - Nature …, 2016 - nature.com
Circulating tumour DNA (ctDNA) analysis facilitates studies of tumour heterogeneity. Here
we employ CAPP-Seq ctDNA analysis to study resistance mechanisms in 43 non-small cell …